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systemic lupus erythematosus 2

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Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 686-700 doi: 10.1007/s11684-022-0957-7

Abstract: Systemic lupus erythematosus (SLE) is a complicated autoimmune disease affecting multiple systems and

Keywords： systemic lupus erythematosus     microbiota     biotherapy    

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 549-561 doi: 10.1007/s11684-022-0965-7

Abstract: of biological processes and has been closely associated with numerous autoimmune diseases, including systemiclupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunityThis study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy.activity and fetal loss during lupus pregnancy.Our findings suggested that IgG influences lupus activity through regulating pDCs function via

Keywords： pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract:

Systemic lupus erythematosus (SLE) is a debilitating autoimmune disorder characterized by unknownare specific for diagnosing SLE, as no significant changes in these biomarkers were observed in other systemicare easily confused with SLE, such as rheumatoid arthritis, primary Sjögren's syndrome, or systemic

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Mycophenolate mofetil or tacrolimus compared with azathioprine in long-term maintenance treatment for active lupus

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 799-807 doi: 10.1007/s11684-021-0849-2

Abstract: mofetil (MMF) or tacrolimus (TAC) compared with azathioprine (AZA) as maintenance therapy for active lupus

Keywords： lupus nephritis     mycophenolate mofetil     tacrolimus     maintenance therapy    

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China’s carbon neutrality: an extensive and profound systemic reform

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1614-3

Abstract:

● China has pledged ambitious carbon peak and neutrality goals for mitigating global climate change.

Keywords： Carbon neutrality     Energy structure     Technology-dependent society     Coordinated mitigation for air pollutants and CO2    

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A systemic review of hydrogen supply chain in energy transition

Frontiers in Energy 2023, Volume 17, Issue 1,   Pages 102-122 doi: 10.1007/s11708-023-0861-0

Abstract: Targeting the net-zero emission (NZE) by 2050, the hydrogen industry is drastically developing in recent years. However, the technologies of hydrogen upstream production, midstream transportation and storage, and downstream utilization are facing obstacles. In this paper, the development of hydrogen industry from the production, transportation and storage, and sustainable economic development perspectives were reviewed. The current challenges and future outlooks were summarized consequently. In the upstream, blue hydrogen is dominating the current hydrogen supply, and an implementation of carbon capture and sequestration (CCS) can raise its cost by 30%. To achieve an economic feasibility, green hydrogen needs to reduce its cost by 75% to approximately 2 /kg at the large scale. The research progress in the midterm sector is still in a preliminary stage, where experimental and theoretical investigations need to be conducted in addressing the impact of embrittlement, contamination, and flammability so that they could provide a solid support for material selection and large-scale feasibility studies. In the downstream utilization, blue hydrogen will be used in producing value-added chemicals in the short-term. Over the long-term, green hydrogen will dominate the market owing to its high energy intensity and zero carbon intensity which provides a promising option for energy storage. Technologies in the hydrogen industry require a comprehensive understanding of their economic and environmental benefits over the whole life cycle in supporting operators and policymakers.

Keywords： hydrogen production     hydrogen transportation and storage     hydrogen economy     carbon capture and sequestration (CCS)     technology assessment    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 465-472 doi: 10.1007/s11684-016-0482-7

Abstract: (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemicsignificantly reduced in ASIC3−/− mice, whereas the systemicanalgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Aβ-fiber, whereas systemic

Keywords： electroacupuncture     analgesia     ASIC3     TRPV1     C-fiber reflex    

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A Review of Development and Management of Systemic Engineering for a Giant Science Expedition in the

Chen Liqi

Strategic Study of CAE 2004, Volume 6, Issue 2,   Pages 1-7

Abstract:

The Arctic and Antarctic is a significant component in the earth system. There are increasing evidences showing that the interaction between human and the earth has become a driving force to the global change. The polar system has been playing an important role as a magnifier and an indicator to the global change. In the period of exchange between the old and the new century, researches on the Arctic and Antarctic system science represent a giant science era. The Arctic and Antarctic system science is not only studying operational mechanism, order, and controlling principle in the response and feedback of the Arctic and Antarctic system to the global change to provide scientific bases for regional complexity and the global change forecasting, but it is also a systematic engineering science to study high innovative technological utility and to improve human's understanding the nature as well as to effectively manage the polar system. In the past 20 years, through the effert by the Chinese Arctic and Antarctic National Research Expedition, Chinese scientists have obtained a further knowledge about the polar system complexity under the global change and the development and management of polar science expedition.

Keywords： global change science     arctic and antarctic system science     systemic engineering management    

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Toward Systemic Thinking in Managing Environmental Risks

Jun Bi, Jianxun Yang, Miaomiao Liu, Zongwei Ma, Wen Fang

Engineering 2021, Volume 7, Issue 11,   Pages 1518-1522 doi: 10.1016/j.eng.2021.06.016

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Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a German experience

Ting Lin, Kai Qu, Xinsen Xu, Min Tian, Jie Gao, Chun Zhang, Ying Di, Yuelang Zhang, Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 118-126 doi: 10.1007/s11684-014-0306-6

Abstract:

Intensive care unit (ICU) is important in the rehabilitation of critically ill patients. In the past decades, many patients who received aggressive treatment in ICU developed sclerosing cholangitis in multiple centers. Sclerosing cholangitis in critically ill patients (SC-CIP) is a relatively new issue. To investigate the causes, clinical manifestation, treatment, and prognosis of SC-CIP, we searched for published cases in the databases of PubMed, Highwire, and Elsevier from 2001 to 2012. Data were extracted using a standard form and retrospectively analyzed. Twelve eligible studies covering 88 patients, with 64 men and 24 women, were enrolled in this analysis. The mean age was 49.8 years. All of the patients recovered from critical illnesses, such as trauma, infection, burn, and major surgeries. High pressure positive end-expiratory pressure (PEEP, peak level at 12.8 cm H2O) was utilized for all patients, with the average duration of 36.3 d. In addition, vasopressor agents were administered in approximately 60% of SC-CIP. A rapid increase in cholestasis and irregular strictures in the intrahepatic bile ducts was observed in the following months. With an average follow-up period of 17.9 months, poor outcomes were observed in 54 patients, including 34 deaths. In conclusion, ischemic injury of the biliary tree, which may be affected by PEEP and/or vasopressor administration, affects cholangiopathic procedure. As a newly discovered type of secondary sclerosing cholangitis, SC-CIP is a severe progressive complication of patients in ICU and should be carefully monitored by clinicians.

Keywords： intensive care unit     sclerosing cholangitis     ischemic injury     prognosis     systemic review    

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Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Article

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Engineering 2021, Volume 7, Issue 8,   Pages 1149-1156 doi: 10.1016/j.eng.2020.09.013

Abstract: In a mouse model of MRSA systemic infection, PNP administration reduced bacterial counts in the blood

Keywords： Nanoparticle     Nanosponge     Platelet     Staphylococcus aureus     Bacterial toxins     Sepsis    

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Title Author Date Type Operation

Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside

Journal Article

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Mycophenolate mofetil or tacrolimus compared with azathioprine in long-term maintenance treatment for active lupus

Journal Article

China’s carbon neutrality: an extensive and profound systemic reform

Journal Article

A systemic review of hydrogen supply chain in energy transition

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Journal Article

A Review of Development and Management of Systemic Engineering for a Giant Science Expedition in the

Chen Liqi

Journal Article

Toward Systemic Thinking in Managing Environmental Risks

Jun Bi, Jianxun Yang, Miaomiao Liu, Zongwei Ma, Wen Fang

Journal Article

Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a German experience

Ting Lin, Kai Qu, Xinsen Xu, Min Tian, Jie Gao, Chun Zhang, Ying Di, Yuelang Zhang, Chang Liu

Journal Article

Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic

Jwa-Kyung Kim, Satoshi Uchiyama, Hua Gong, Alexandra Stream, Liangfang Zhang, Victor Nizet

Journal Article